Tolerance induction via a B-cell delivered gene therapy-based protocol: optimization and role of the Ig scaffold.

Our previous studies indicated that antigen-specific tolerance could be achieved by the injection of LPS-activated B-cell blasts that were retrovirally gene-transferred with an IgG-antigen fusion construct. This system was shown to be effective for tolerance induction with a variety of inserted antigens ranging in size from a single peptide to a large multi… CONTINUE READING