Tolerance induction in mice by conjugates of monoclonal immunoglobulins and monomethoxypolyethylene glycol. Transfer of tolerance by T cells and by T cell extracts.

@article{Wilkinson1987ToleranceII,
  title={Tolerance induction in mice by conjugates of monoclonal immunoglobulins and monomethoxypolyethylene glycol. Transfer of tolerance by T cells and by T cell extracts.},
  author={Ian Wilkinson and Christopher J. Jackson and Glen M. Lang and Valerie Christine Holford-Strevens and Alec H. Sehon},
  journal={Journal of immunology},
  year={1987},
  volume={139 2},
  pages={
          326-31
        }
}
The specific tolerance induced in mice by conjugates of human monoclonal IgG (HIgG) with monomethoxypolyethylene glycol (mPEG) was transferred to normal mice by spleen cells or a surface immunoglobulin negative (sIg-) Lyt-2+ subpopulation of these cells. Although transferable tolerance was demonstrable 6 to 14 days after treatment of the cell donors with tolerogen, the state of tolerance persisted in the treated mice for at least 43 days. Moreover, an extract prepared by freezing and thawing of… CONTINUE READING

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