Tolerance induction by gene transfer to lymphocytes.

  title={Tolerance induction by gene transfer to lymphocytes.},
  author={Jonathan Skupsky and Yan Gui Su and Tie-Chi Lei and David W Scott},
  journal={Current gene therapy},
  volume={7 5},
Tolerance must be maintained to prevent deleterious immune responses. Thus, when tolerance is lost, autoimmunity can result. A number of novel approaches to (re-) induce tolerance for potential clinical applications have been developed in the last decade. Our lab has implemented an immunoglobulin-based gene therapy approach, which may have powerful implications for the treatment of human conditions. These include a variety of autoimmune diseases, transplantation, and the immune response to… CONTINUE READING


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