Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1

@article{Albrecht2008ToleranceIV,
  title={Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1},
  author={Valerie Albrecht and Thomas P. J. Hofer and Brian M. J. Foxwell and Marion Frankenberger and Loems Ziegler-Heitbrock},
  journal={BMC Immunology},
  year={2008},
  volume={9},
  pages={69 - 69}
}
While dendritic cells (DCs) can induce tolerance in T cells, little is known about tolerance induction in DCs themselves. We have analysed tolerance induced in human in-vitro generated DCs by repeated stimulation with ligands for TLR4 and TLR2. DCs stimulated with the TLR4 ligand LPS did show a rapid and pronounced expression of TNF mRNA and protein. When DCs were pre-cultured for 2 days with 5 ng LPS/ml then the subsequent response to stimulation with a high dose of LPS (500 ng/ml) was… CONTINUE READING

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