Tolerance does not develop to the decrease in nicotine self-administration produced by repeated bupropion administration.

@article{Rauhut2005ToleranceDN,
  title={Tolerance does not develop to the decrease in nicotine self-administration produced by repeated bupropion administration.},
  author={Anthony Sean Rauhut and Linda P. Dwoskin and Michael T. Bardo},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2005},
  volume={7 6},
  pages={901-7}
}
The atypical antidepressant bupropion has been shown to be an efficacious smoking cessation agent; however, its therapeutic mechanism of action is unknown. To further understand the mechanism by which bupropion reduces smoking, the present study determined the effect of repeated bupropion pretreatment on nicotine self-administration or sucrose-maintained responding. Rats were trained to self-administer intravenous nicotine (0.02 mg/kg/infusion; Experiment 1) or to respond for sucrose pellets… CONTINUE READING

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