Tolerance and sensitization to stimulant and depressant effects of nicotine in intracranial self-stimulation in the rat.

@article{Herberg1993ToleranceAS,
  title={Tolerance and sensitization to stimulant and depressant effects of nicotine in intracranial self-stimulation in the rat.},
  author={L. J. Herberg and A Montgomery and I C Rose},
  journal={Behavioural pharmacology},
  year={1993},
  volume={4 4},
  pages={419-427}
}
Nicotine is thought to be an important factor in addiction to tobacco but its psychopharmacological properties are still uncertain. In the present study, rats were trained to operate a pedal to obtain threshold-current, variable-interval hypothalmic stimulation. Response rates were printed out at 10min intervals to provide a continuous record of… CONTINUE READING