Tolerance and pharmacokinetics of single-dose atorvastatin, a potent inhibitor of HMG-CoA reductase, in healthy subjects.

@article{Posvar1996ToleranceAP,
  title={Tolerance and pharmacokinetics of single-dose atorvastatin, a potent inhibitor of HMG-CoA reductase, in healthy subjects.},
  author={Edward L Posvar and Louis L. Radulovic and D D Cilla and Lloyd R. Whitfield and Allen J. Sedman},
  journal={Journal of clinical pharmacology},
  year={1996},
  volume={36 8},
  pages={728-31}
}
Tolerance and pharmacokinetics after single-dose administration of atorvastatin, an investigational inhibitor of HMG-CoA reductase, were examined in 22 healthy volunteers in a three-period, partially-blinded study. Participants received capsule and solution doses of atorvastatin (0.5 to 120 mg) and placebo at weekly intervals. Atorvastatin was well tolerated at doses as high as 80 mg. The adverse event profile was similar after administration of atorvastatin capsules and placebo. Atorvastatin… CONTINUE READING

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