Tolerance and loss of beneficial effect during migraine prophylaxis: clinical considerations.

@article{Loder2011ToleranceAL,
  title={Tolerance and loss of beneficial effect during migraine prophylaxis: clinical considerations.},
  author={Elizabeth Loder and Paul B Rizzoli},
  journal={Headache},
  year={2011},
  volume={51 8},
  pages={1336-45}
}
A familiar situation in migraine treatment is the patient with an initial positive response to prophylactic drug therapy who later experiences relapse. The goals of this paper are to provide a theoretical framework to help doctors think about this problem, to evaluate factors and response patterns that may be associated with different causes of relapse, and to suggest clinical strategies that may aid in its management. Six key explanations for loss of benefit from prophylactic therapy are: (1… CONTINUE READING

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