Tolerance and efficacy of gemcitabine and gemcitabine-based regimens in elderly patients with advanced pancreatic cancer.

@article{Marchal2008ToleranceAE,
  title={Tolerance and efficacy of gemcitabine and gemcitabine-based regimens in elderly patients with advanced pancreatic cancer.},
  author={Rapha{\"e}l Mar{\'e}chal and Anne Demols and France Gay and Viviane de Maertelaer and Marianna Arvanitaki and Alain Hendlisz and Jean-Luc van Laethem},
  journal={Pancreas},
  year={2008},
  volume={36 3},
  pages={e16-21}
}
OBJECTIVES Gemcitabine is the backbone therapy of patients with advanced pancreatic cancer. Its tolerability and efficacy remain poorly studied in elderly. METHODS We selected patients coming from phase 2 and 3 studies, conducted between January 2001 and December 2004 in our department, evaluating gemcitabine-based first-line chemotherapy. We evaluated the treatment efficacy, tolerability, and compared patients younger than 70 years (group A) and aged 70 years and older (group B). We assessed… CONTINUE READING
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