Tolerance and cross-tolerance among psychotomimetic drugs

@article{Appel1968ToleranceAC,
  title={Tolerance and cross-tolerance among psychotomimetic drugs},
  author={James B. Appel and Daniel X. Freedman},
  journal={Psychopharmacologia},
  year={1968},
  volume={13},
  pages={267-274}
}
A fixed-ratio schedule of milk reinforcement (FR 30) was used to study tolerance to the effects of d-LSD, l-LSD, BOL, psilocybin, mescaline, and d-amphetamine in the rat. A decrease in the amount of disruption of bar-pressing occurs with repeated daily administration of appropriate doses of all of the “psychotomimetic” compounds, and cross-tolerance was also demonstrated.