Tolerance and autoimmunity.

@article{Kamradt2001ToleranceAA,
  title={Tolerance and autoimmunity.},
  author={Thomas Kamradt and Neil Mitchison},
  journal={The New England journal of medicine},
  year={2001},
  volume={344 9},
  pages={
          655-64
        }
}
The immunologic specificity of the antigen receptors of T cells and B cells is the result of random shuffling of the many genes that form the DNA code for the antigen-binding site of these receptors.1–3 Theoretically, this process could generate 109 different T-cell receptors, including some that can bind to autoantigens (these cells are often called self-reactive T cells). Tolerance is the process that eliminates or neutralizes such autoreactive cells, and a breakdown in the working of this… 
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