Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

@article{Porta2009ToleranceAM,
  title={Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.},
  author={Chiara Porta and Monica Rimoldi and Geert Raes and Lea Brys and Pietro Ghezzi and Diana Di Liberto and Francesco Dieli and Serena Ghisletti and Gioacchino Natoli and Patrick de Baetselier and Alberto Mantovani and Antonio Sica},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 35},
  pages={14978-83}
}
Cells of the monocyte-macrophage lineage play a central role in the orchestration and resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response to environmental signals these cells undergo different forms of polarized activation, the extremes of which are called classic or M1 and alternative or M2. NF-kappaB is a key regulator of inflammation and resolution, and its activation is subject to multiple levels of regulation, including inhibitory, which finely… CONTINUE READING