Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test.


Balb/c mice were exposed to an elevated platform that is extended on two opposite sides with lowered steep slopes. They were tested for 12min per session in 6 successive days. They received i.p. administration of either saline or one dose of diazepam (DZP 0.5, 1, 3mg/kg) in sessions 1-3, and saline in sessions 4 and 5. All groups of mice received a single… (More)
DOI: 10.1016/j.bbr.2010.01.039

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