Tolerability of two sequential electroporation treatments using MedPulser DNA delivery system (DDS) in healthy adults.

@article{Wallace2009TolerabilityOT,
  title={Tolerability of two sequential electroporation treatments using MedPulser DNA delivery system (DDS) in healthy adults.},
  author={Mark S. Wallace and Barbara Evans and Sandra D Woods and Robin Mogg and Lei Zhang and Adam C. Finnefrock and Dietmar Rabussay and Michael Fons and John J Mallee and Devan V. Mehrotra and Florian P Sch{\"o}del and Luwy Musey},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 5},
  pages={922-8}
}
Immunotherapy against infectious agents and malignant tumors requires efficient priming of effector cells through direct expression and/or efficient cross-presentation of antigens by antigen-presenting cells. Electroporation is a new procedure aimed at transiently increasing cell membrane permeability and direct delivery of antigen or antigen-encoding nucleic acids inside targeted cells. We evaluated the tolerability including compliance with repeated electroporation treatments using MedPulser… CONTINUE READING

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