Tolerability of paroxetine in Parkinson's disease: a prospective study.

  title={Tolerability of paroxetine in Parkinson's disease: a prospective study.},
  author={Silvana Tesei and Angelo Antonini and Margherita Canesi and Anna Lena Zecchinelli and Claudio Mariani and Gianni Pezzoli},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={15 5},
Depression is a common finding in patients with Parkinson's disease (PD). Traditionally, depression has been treated with tricyclic antidepressants, which are often associated with undesirable side effects that may limit their use in PD. Few studies have been performed with selective serotonin reuptake inhibitors (SSRIs) in these patients. We assessed the tolerability of the SSRI antidepressant paroxetine (10-20 mg once per day) in 65 outpatients with PD and depression for a period of at least… CONTINUE READING