Tolerability of carvedilol and ACE-Inhibition in mild heart failure. Results of CARMEN (Carvedilol ACE-Inhibitor Remodelling Mild CHF EvaluatioN).

@article{Komajda2004TolerabilityOC,
  title={Tolerability of carvedilol and ACE-Inhibition in mild heart failure. Results of CARMEN (Carvedilol ACE-Inhibitor Remodelling Mild CHF EvaluatioN).},
  author={Michel Komajda and Beatrix Lutiger and Hugo Costa Madeira and Kristian Thygesen and Marco Bobbio and P. D. Hildebrandt and Wybren Jaarsma and Guenter A. J. Riegger and Lars Ryd{\'e}n and Armin Scherhag and Jordi Soler-Soler and Willem J. Remme},
  journal={European journal of heart failure},
  year={2004},
  volume={6 4},
  pages={467-75}
}
BACKGROUND Management guidelines for heart failure recommend ACE-I and beta-blockers. The perception of difficult up-titration might have added to the slow uptake of beta-blockers despite their mortality and morbidity benefits. AIMS CARMEN offered a possibility to study safety and tolerability of enalapril against carvedilol and their combination. METHODS Five hundred and seventy-two patients were blindly up-titrated on carvedilol (target 25 mg bid) and/or enalapril (target 10 mg bid), and… CONTINUE READING

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