Tolerability of amine uptake inhibitors in urologic diseases.

  title={Tolerability of amine uptake inhibitors in urologic diseases.},
  author={Martin C. Michel and Henricus Gerardus Ruh{\'e} and Annemieke A de Groot and Ramiro S Castro and Matthias Oelke},
  journal={Current drug safety},
  volume={1 1},
Inhibitors of serotonin (5-HT) and/or noradrenaline (NA) reuptake have been developed for pharmacological treatment of major depressive disorder. Insights in the role of 5-HT and NA in the neurological control of the lower urinary tract have also led to their application in common urological conditions such as stress urinary incontinence (SUI), nocturnal enuresis and ejaculatory disorders. The European approval of the 5-HT and NA reuptake inhibitor (SNRI) duloxetine for treatment of SUI… CONTINUE READING