Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies

@article{Roberts2016TolerabilityAP,
  title={Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1 Studies},
  author={Tracey M. Roberts and John F Kokai-Kun and Olivia Coughlin and Barbara Valero Lopez and Heidi Whalen and Jillian A Bristol and Steven Hubert and James Longstreth and Kenneth C. Lasseter and Joseph Sliman},
  journal={Clinical Drug Investigation},
  year={2016},
  volume={36},
  pages={725-734}
}
  • Tracey M. Roberts, John F Kokai-Kun, +7 authors Joseph Sliman
  • Published in Clinical Drug Investigation 2016
  • Medicine
  • BackgroundSYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous β-lactam antibiotics like cephalosporins. SYN-004 is intended to degrade residual antibiotics excreted into the intestine as a result of hepatobiliary excretion and to prevent the disruption of the gut microbiome by these excess antibiotics. Preserving the gut microbiome is expected to prevent secondary infections by pathogens like Clostridium difficile and protect against… CONTINUE READING

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