Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.

@article{Yuan2005TolerabilityGE,
  title={Tolerability, gut effects, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.},
  author={Chun-Su Yuan and Harold Doshan and Martha R Charney and Michael O'Connor and Theodore M. Karrison and Spring Maleckar and Robert Joseph Israel and Jonathan B Moss},
  journal={Journal of clinical pharmacology},
  year={2005},
  volume={45 5},
  pages={538-46}
}
Previous studies have shown that a single dose of methylnaltrexone, a unique peripheral opioid antagonist, reverses opioid-induced gut hypomotility in humans. Because repeated drug doses are likely to be needed to treat patients with opioid-induced or postsurgical bowel dysfunction, the authors have now examined the safety, pharmacological activity, and pharmacokinetics of a multiple-dose regimen of methylnaltrexone, administered as 12 consecutive intravenous doses (0.3 mg/kg every 6 hours) in… CONTINUE READING