Tolerability, Pharmacokinetics, and Neuroendocrine Effects of PRX‐00023, a Novel 5‐HT1A Agonist, in Healthy Subjects

@article{Iyer2007TolerabilityPA,
  title={Tolerability, Pharmacokinetics, and Neuroendocrine Effects of PRX‐00023, a Novel 5‐HT1A Agonist, in Healthy Subjects},
  author={Ganesh R. Iyer and John F. Reinhard Jr and Scott Oshana and Michael G. Kauffman and Stephen Donahue},
  journal={The Journal of Clinical Pharmacology},
  year={2007},
  volume={47}
}
PRX‐00023 is a novel, nonazapirone 5‐HT1A agonist in clinical development for treatment of affective disorders. The objectives of the initial clinical phase I studies (a single ascending dose study and multiple dose‐ascending and high‐dose titration studies) were to measure the pharmacokinetics, pharmacodynamic (neuroendocrine) effects, and tolerability of PRX‐00023 in healthy subjects. The studies evaluated 10‐mg to 150‐mg doses of PRX‐00023 in up to 112 healthy male and female subjects aged… 

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