Tolcapone Improves Cognition and Cortical Information Processing in Normal Human Subjects

@article{Apud2007TolcaponeIC,
  title={Tolcapone Improves Cognition and Cortical Information Processing in Normal Human Subjects},
  author={Jose Apud and Venkata S. Mattay and Jingshan Chen and Bhaskar S. Kolachana and Joseph H. Callicott and Roberta Rasetti and Guilna Alce and Jennifer Iudicello and Natkai Akbar and Michael Egan and Terry E. Goldberg and Daniel R. Weinberger},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={1011-1020}
}
Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory. Efforts to enhance prefrontal-related cognition, which have focused on catecholaminergic stimulant drugs, have been unsatisfactory. Recently, the demonstration that a functional polymorphism in the catecholamine-O-methyltransferase (COMT) gene impacts prefrontal cognition raises the possibility of a novel pharmacological approach for the treatment of prefrontal lobe… 
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