Tolbutamide does not alter insulin requirement in Type 1 (insulin-dependent) diabetes

Abstract

We examined whether tolbutamide has any acute or short-term effects on insulin action in Type 1 (insulin-dependent) diabetes. A euglycaemic glucose clamp was performed in seven Type 1 diabetic patients without clinical insulin resistance by infusing glucose at a constant rate of 0.01 mmol·kg-1·min-1 for 3 h together with a simultaneous insulin infusion… (More)
DOI: 10.1007/BF00253493

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