Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy.

@article{Miyamoto2000Tol1AF,
  title={Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy.},
  author={Ryan Miyamoto and Reiko Sugiura and Shigeki Kamitani and Tomoko Yada and Yan Lu and Susie Ong Sio and Masumi Asakura and Akio Matsuhisa and Hisato Shuntoh and Takayoshi Kuno},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 13},
  pages={3619-25}
}
Lithium is the drug of choice for the treatment of bipolar affective disorder. The identification of an in vivo target of lithium in fission yeast as a model organism may help in the understanding of lithium therapy. For this purpose, we have isolated genes whose overexpression improved cell growth under high LiCl concentrations. Overexpression of tol1(+), one of the isolated genes, increased the tolerance of wild-type yeast cells for LiCl but not for NaCl. tol1(+) encodes a member of the… CONTINUE READING

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