Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial
@article{Bachelez2015TofacitinibVE, title={Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial}, author={Herv{\'e} Bachelez and Peter van de Kerkhof and Robert Strohal and Alexey A. Kubanov and Fernando Valenzuela and Joo-Heung Lee and Vladimir V Yakusevich and Sergio Chimenti and Jocelyne Papacharalambous and James Proulx and Pankaj Gupta and Huaming Tan and Margaret Tawadrous and Hernan Valdez and Robert Wolk}, journal={The Lancet}, year={2015}, volume={386}, pages={552-561} }
325 Citations
Oral tofacitinib efficacy, safety and tolerability in Japanese patients with moderate to severe plaque psoriasis and psoriatic arthritis: A randomized, double‐blind, phase 3 study
- MedicineThe Journal of dermatology
- 2016
Tofacitinib (both doses) demonstrated efficacy in patients with moderate to severe plaque psoriasis and/or psoriatic arthritis through 52 weeks; safety findings were generally consistent with prior studies.
Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo‐controlled phase 3 trial
- MedicineThe Journal of dermatology
- 2017
Results were generally consistent with global analysis, suggesting sustained efficacy and a manageable safety profile, with increased herpes zoster incidence, of tofacitinib in Japanese patients with psoriasis.
The efficacy and safety of tofacitinib in Asian patients with moderate to severe chronic plaque psoriasis: A Phase 3, randomized, double-blind, placebo-controlled study.
- MedicineJournal of dermatological science
- 2017
Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial
- MedicineBMC Dermatology
- 2016
In adults with mild to moderate plaque psoriasis, 2 % tofacitinib ointment QD and BID showed greater efficacy than vehicle at Week 8, but not Week 12, with an acceptable safety and local tolerability profile.
Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: Long-term efficacy and safety results from 2 randomized phase-III studies and 1 open-label long-term extension study.
- MedicineJournal of the American Academy of Dermatology
- 2016
Efficacy of tofacitinib for the treatment of nail psoriasis: Two 52‐week, randomized, controlled phase 3 studies in patients with moderate‐to‐severe plaque psoriasis
- MedicineJournal of the American Academy of Dermatology
- 2017
Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF Inhibitors
- Medicine, PsychologyThe New England journal of medicine
- 2017
In this trial involving patients with active psoriatic arthritis who had had an inadequate response to TNF inhibitors, tofacitinib was more effective than placebo over 3 months in reducing disease activity.
Tofacitinib in Pediatric Psoriasis: An Open-Label Trial to Study Its Safety and Efficacy in Children
- MedicineDermatology
- 2019
The treatment with tofacitinib was safe and well tolerated, and led to significant improvement of their disease and quality of life as reflected in CDLQI scores, however, the results need to be validated in larger multicenter trials.
Oral tofacitinib for the treatment of adults with moderate to severe chronic plaque psoriasis
- Medicine, BiologyExpert review of clinical pharmacology
- 2016
An effective oral treatment without the organ toxicities of methotrexate and cyclosporine, tofacitinib is a promising alternative to biologics in the treatment of moderate-to-severe psoriasis.
Long‐term safety data for tofacitinib, an oral Janus kinase inhibitor, for the treatment for psoriasis
- MedicineThe British journal of dermatology
- 2018
The safety data for tofacitinib from this open-label extension study are consistent with those previously reported and small increases in mean low-density and high-density lipoprotein cholesterol levels appeared stable during the study.
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