Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers

@article{Kotsopoulos2009ToenailSS,
  title={Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers},
  author={Joanne Kotsopoulos and Zhou Dan-Lin Chen and Katherine Anne Vallis and Aletta Poll and Parviz Ghadirian and Greg Kennedy and Peter Mark Ainsworth and Steven A Narod},
  journal={Cancer Causes & Control},
  year={2009},
  volume={21},
  pages={679-687}
}
Selenium is an important cofactor of various antioxidant enzymes and has been shown to enhance DNA repair in normal human fibroblasts. Oral selenium supplementation has also been shown to decrease the number of chromosome breaks in BRCA1 mutation carriers. Because the predisposition to cancer among BRCA1 mutation carriers may be linked to high rates of DNA damage and chromosome breakage, we evaluated the association between toenail selenium concentrations and three measures of DNA repair… CONTINUE READING