Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

Abstract

Toddler/Apela/Elabela is a conserved secreted peptide that regulates mesendoderm development during zebrafish gastrulation. Two non-exclusive models have been proposed to explain Toddler function. The 'specification model' postulates that Toddler signaling enhances Nodal signaling to properly specify endoderm, whereas the 'migration model' posits that… (More)
DOI: 10.7554/eLife.22626

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