Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.

@article{McAnally2007TocotrienolsPL,
  title={Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo.},
  author={Jennifer A McAnally and Jagriti Gupta and Shradha Sodhani and Lou Bravo and Huanbiao Mo},
  journal={Experimental biology and medicine},
  year={2007},
  volume={232 4},
  pages={523-31}
}
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase is the rate-limiting enzyme in the mevalonate pathway that provides essential intermediates for the membrane anchorage and biologic functions of growth-related proteins. Contrary to preclinical studies showing the growth-suppressive activity of statins, competitive inhibitors of HMG CoA reductase, clinical application of statins in cancer is precluded by their lack of activity at levels prescribed for the prevention of cardiovascular… CONTINUE READING