Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy.

  title={Tocotrienols: balancing the mitochondrial crosstalk between apoptosis and autophagy.},
  author={Eva Cristina Vaquero and Mariana Rickmann and Xavier Molero},
  volume={3 6},
Tocotrienols are a group of natural vitamin E compounds with patent antitumoral effects, mostly based on their ability to induce apoptosis in cancer cells. In activated pancreatic stellate cells (PSCs) we have determined that tocotrienols elicit a dramatic mitochondrial destabilization followed by initiation of non-necrotic forms of programmed cell death, namely apoptosis and autophagy. PSCs are the main cell type involved in the generation of pancreatic fibrosis, and their removal is critical… CONTINUE READING
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