Tocotrienol prevents AAPH-induced neurite degeneration in neuro2a cells.

  title={Tocotrienol prevents AAPH-induced neurite degeneration in neuro2a cells.},
  author={Koji Fukui and Hidekazu Sekiguchi and Hirokatsu Takatsu and Taisuke Koike and Tatsuro Koike and Shiro Urano},
  journal={Redox report : communications in free radical research},
  volume={18 6},
OBJECTIVES Reactive oxygen species induce neurite degeneration before inducing cell death. However, the degenerative mechanisms have not yet been elucidated. While tocotrienols have a known neuroprotective function, the underlying mechanism remains unclear and may or may not involve antioxidant action. In this study, we hypothesize that free radical-derived membrane injury is one possible mechanism for inducing neurite degeneration. Therefore, we examined the potential neuroprotective effect of… CONTINUE READING