Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha.

Abstract

Tocotrienol (T3), unsaturated vitamin E, has recently gained considerable attention as a potent antiangiogenic agent minimizing tumor growth, the exact intracellular mechanisms of which remain poorly understood. Because hypoxia-inducible factor-1alpha (HIF-1alpha), its downstream target vascular endothelial growth factor (VEGF), and other angiogenic factors… (More)
DOI: 10.3945/jn.108.093237

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@article{Shibata2008TocotrienolIS, title={Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha.}, author={Akira Shibata and Kiyotaka Nakagawa and Phumon Sookwong and Tsuyoshi Tsuduki and Shuhei Tomita and Hitoshi Shirakawa and Michio Komai and Teruo Miyazawa}, journal={The Journal of nutrition}, year={2008}, volume={138 11}, pages={2136-42} }