• Corpus ID: 46653868

Tocopherols and Tocotrienols : Similarities and Differences

@inproceedings{Papas2005TocopherolsAT,
  title={Tocopherols and Tocotrienols : Similarities and Differences},
  author={Andreas M. Papas and James H. Quillen},
  year={2005}
}
Tocotrienols are members of the vitamin E family.1 Unlike some vitamins which consist of a single compound, vitamin E consists of eight different compounds: four tocopherols and four tocotrienols (designated as alpha, beta, gamma, and delta). Our food contains all eight compounds. Most vitamin E supplements, however, contain only alpha-tocopherol because it was thought that only this one was important. Emerging research proved this understanding wrong. To get the full spectrum of the many… 

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Surprising was that the largest fraction of skin vitamin E following topical application was found in the deeper subcutaneous layers--the lowest layers, PD and D, contained the major portion of the applied vitamin E forms.

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gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells.

Cyclooxygenase-2 (COX-2)-catalyzed synthesis of prostaglandin E(2) (PGE(2)) plays a key role in inflammation and its associated diseases, such as cancer and vascular heart disease. Here we report

A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations.

The tocotrienol supplements used had no marked favorable effects on the serum lipoprotein profile or on platelet function in men with slightly elevated lipid concentrations.