Tocopherols and 6-hydroxy-chroman-2-carbonitrile derivatives inhibit vascular smooth muscle cell proliferation by a nonantioxidant mechanism.

@article{Boscoboinik1995TocopherolsA6,
  title={Tocopherols and 6-hydroxy-chroman-2-carbonitrile derivatives inhibit vascular smooth muscle cell proliferation by a nonantioxidant mechanism.},
  author={D. Boscoboinik and N. Ozer and U. Moser and A. Azzi},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={318 1},
  pages={
          241-6
        }
}
  • D. Boscoboinik, N. Ozer, +1 author A. Azzi
  • Published 1995
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • The effects of two groups of similar compounds, a series of tocopherols and one of 6-hydroxy-chroman-2-carbonitrile, have been studied in vascular smooth muscle cells. A poor correlation has been found between antiproliferative and antioxidant properties of these molecules. D-alpha-Tocopherol inhibits cell proliferation, while D-alpha-tocopherylquinone has been found neither to inhibit nor to activate. D-beta-Tocopherol, a poor inhibitor of smooth muscle cell proliferation, has been shown to be… CONTINUE READING
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