Tocolysis for acute preterm labor: does anything work

@article{Haram2015TocolysisFA,
  title={Tocolysis for acute preterm labor: does anything work},
  author={Kjell Haram and Jan Helge Seglem Mortensen and John Morrison},
  journal={The Journal of Maternal-Fetal \& Neonatal Medicine},
  year={2015},
  volume={28},
  pages={371 - 378}
}
Abstract The central rationale of tocolysis for preterm labor (PTL) is to delay delivery for at least 48 h to allow for transfer of the mother to a tertiary facility and for corticosteroids to induce surfactant production in fetal lungs. Beta-mimetics decrease the number of women in preterm labor giving birth within 48 h without reducing adverse neonatal outcomes. Calcium channel blockers inclusive of nifedipine decrease the adverse neonatal outcomes by significantly delaying delivery. Atosiban… Expand
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TLDR
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References

SHOWING 1-10 OF 78 REFERENCES
Controversies in tocolytic therapy.
TLDR
It is doubtful, because of the nature of tocolytics, that newer to colytics will be developed that will eliminate the problems of preterm delivery, but careful guidelines must be observed. Expand
Use of tocolytics: what is the benefit of gaining 48 hours for the fetus?
TLDR
There is ample evidence that tocolysis delays delivery for long enough to permit administration of a complete course of antepartum glucocorticoids and to facilitate in utero transfer to a tertiary care unit where neonatal care will be optimal. Expand
Management of preterm labor: atosiban or nifedipine?
TLDR
The available evidence, the pros and cons of either drug, and information to support a balanced choice of first-line tocolytic drug: atosiban or nifedipine are discussed. Expand
Tocolytic therapy for acute preterm labor.
TLDR
This article has provided a summary of the most commonly used tocolytic agents, their mechanisms of action, side effects, and clinical data regarding their efficacy. Expand
Prematurity prevention: the role of acute tocolysis
TLDR
This review will summarize the most common acute tocolytic drugs, their methods of action, and clinical data regarding their utility. Expand
Preterm labour. Pharmacological prevention of prematurity.
  • K. Groom
  • Medicine
  • Best practice & research. Clinical obstetrics & gynaecology
  • 2007
TLDR
The acute treatment of premature labour is successful for delaying delivery for short periods of time, and the use of progesterone in women with a history of very early preterm labour is likely to be beneficial for preventing pre term labour. Expand
Pharmacological prevention of prematurity
TLDR
The acute treatment of premature labour is successful for delaying delivery for short periods of time, and the use of progesterone in women with a history of very early preterm labour is likely to be beneficial for preventing pre term labour. Expand
TOCOLYTIC DRUGS FOR WOMEN IN PRETERM LABOUR
  • 2003
Preterm birth is the most important single determinant of adverse infant outcome, in terms of both survival and quality of life. Although preterm birth is defined as being before 37 completed weeks,Expand
Effect of antenatal tocolysis on neonatal outcomes
  • C. Klauser, C. Briery, S. Keiser, Rick W. Martin, M. Kosek, J. Morrison
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2012
TLDR
There were no statistically significant differences between the three tocolytic drugs as far as composite neonatal morbidity or mortality was concerned. Expand
The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban
TLDR
Atosiban was developed specifically to treat preterm labor, so the cost is higher than nifedipine or ritodrine, but the balance of evidence indicates that atosiban is as effective as nifesiban and more effective than β-agonists and is significantly safer than both. Expand
...
1
2
3
4
5
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