Tocilizumab in the treatment of systemic juvenile idiopathic arthritis

  title={Tocilizumab in the treatment of systemic juvenile idiopathic arthritis},
  author={Miho Murakami and Minako Tomiita and Norihiro Nishimoto},
  booktitle={Open access rheumatology : research and reviews},
Systemic juvenile idiopathic arthritis is one of the common rheumatic diseases in childhood and characterized by spiking fever, evanescent skin rash, lymphadenopathy, hepatosplenomegaly, and serositis, in addition to arthritis. Children with systemic juvenile idiopathic arthritis often show growth retardation and developmental abnormality, as well as macrophage activation syndrome, a life-threatening complication. Overproduction of interleukin-6 is pathologically responsible for the systemic… CONTINUE READING