Tobramycin levels in cerebrospinal fluid of patients with slightly and severely impaired blood-cerebrospinal barrier.

Abstract

Concentrations of tobramycin in cerebrospinal fluid (CSF) and serum of neurosurgical and of meningitis patients were determined following systemic application of 80-mg doses. Tobramycin was detectable only in 8 tests out of 17 in CSF of 11 neurosurgical patients. The highest drug amount in CSF in these tests was 0.47 microgram/ml. In CSF of 7 meningitis… (More)

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@article{Brueckner1981TobramycinLI, title={Tobramycin levels in cerebrospinal fluid of patients with slightly and severely impaired blood-cerebrospinal barrier.}, author={O J Brueckner and M. Alexander and Hartmut Collmann}, journal={Chemotherapy}, year={1981}, volume={27 5}, pages={303-8} }