Tobramycin: A Review of its Antibacterial and Pharmacokinetic Properties and Therapeutic Use

@article{Brogden2012TobramycinAR,
  title={Tobramycin: A Review of its Antibacterial and Pharmacokinetic Properties and Therapeutic Use},
  author={Rex N. Brogden and Roger Martin Pinder and Phyllis R. Sawyer and Trevor M. Speight and Graeme S. Avery},
  journal={Drugs},
  year={2012},
  volume={12},
  pages={166-200}
}
SummarySynopsis: Tobramycin is a new aminoglycoside antibiotic with a broad antibacterial spectrum in vitro, and pharmacokinetic properties similar to those for gentamicin. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains, but is not active against enterobacteriaceae resistant to gentamicin.Theoretically, tobramycin has an advantage over gentamicin against infections caused by P. aeruginosa, but any advantage in… 
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Tobramycin is an aminoglycoside antibiotic which has excellent antibacterial activity against Pseudomonas, Staphylococcus aureus, and many members of the Enterobacteriaceae. Most strains of Serratia,
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