Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence.

@article{Maxwell2010TobaccoUI,
  title={Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence.},
  author={Jessica H Maxwell and B. Tejeswar Kumar and Felix Feng and Francis Paul Worden and Julia Shin-Jung Lee and Avraham Eisbruch and G T Wolf and Mark E. P. Prince and Jeffrey S. Moyer and Theodoros Teknos and Douglas B. Chepeha and Jonathan McHugh and Susan G. Urba and Jay A. Stoerker and Heather M. Walline and David M. Kurnit and Kitrina G Cordell and Samantha J. Davis and Preston Daniel Ward and Carol R. Bradford and Thomas E. Carey},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 4},
  pages={1226-35}
}
PURPOSE The goal of this study was to examine the effect of tobacco use on disease recurrence (local/regional recurrence, distant metastasis, or second primary) among patients with human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP) following a complete response to chemoradiation therapy. EXPERIMENTAL DESIGN Between 1999 and 2007, 124 patients with advanced SCCOP (86% with stage IV) and adequate tumor tissue for HPV analysis who were enrolled in one of two… CONTINUE READING

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