Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase.

@article{Selman1996TobaccoSL,
  title={Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase.},
  author={Mois{\'e}s Selman and Martha Monta{\~n}o and Carlos Ramos and Beatriz Vanda and Carina Becerril and Jer{\'o}nimo Delgado and Ra{\'u}l Sansores and Roberto Barrios and Annie Pardo},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 1},
  pages={L734-43}
}
We examined the expression of interstitial collagenase and its enzymatic activity in lung damage induced by tobacco smoke. Guinea pigs were exposed to the smoke of 20 cigarettes per day from 1-8 wk. Age-matched guinea pigs were used as controls. At 6 and 8 wk of smoke exposure, lungs exhibited interstitial and peribronchiolar inflammation and moderate emphysematous changes. In situ hybridization of injured lungs revealed patchy expression of collagenase mRNA mainly in macrophages but also in… CONTINUE READING

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