Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism.

  title={Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism.},
  author={Sherry B. Hildreth and Elizabeth A Gehman and Haibing Yang and R Lu and kumar. ritesh and Kim C Harich and Shi Yu and Jinshan Ella Lin and Jackson L. Sandoe and Sakiko Okumoto and Angus S Murphy and John G Jelesko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 44},
An effective plant alkaloid chemical defense requires a variety of transport processes, but few alkaloid transporters have been characterized at the molecular level. Previously, a gene fragment encoding a putative plasma membrane proton symporter was isolated, because it was coordinately regulated with several nicotine biosynthetic genes. Here, we show that this gene fragment corresponds to a Nicotiana tabacum gene encoding a nicotine uptake permease (NUP1). NUP1 belongs to a plant-specific… CONTINUE READING
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