Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

  title={Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.},
  author={Michele L Cote and Wonsuk Yoo and Angela S. Wenzlaff and Geoffrey M Prysak and Susan K Santer and Gina B. Claeys and Alison L Van Dyke and Susan J. Land and Ann Grossbart Schwartz},
  volume={30 4},
To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2005. Population-based controls (n = 527) were identified through random digit dialing and matched on race and age. Eleven SNPs in 10 different genes were examined in relation to… CONTINUE READING
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