Tobacco, alcohol, and colorectal tumors: a multistep process.

  title={Tobacco, alcohol, and colorectal tumors: a multistep process.},
  author={Marie Christine Boutron and Jean Faivre and M C Dop and V. Quipourt and Pierre Senesse},
  journal={American journal of epidemiology},
  volume={141 11},
A case-control study in the Côte d'Or area of France used the multistep concept of colorectal carcinogenesis to compare lifetime tobacco consumption and present alcohol consumption in patients with small adenomas (less than 1 cm, n = 154) or large adenomas (n = 208) and in polyp-free controls (n = 427). Cancer patients (n = 171) were compared with population controls (n = 309). In men, smoking was associated with the risk of adenomas (odds ratio = 3.6 over 20 pack-years vs. nonsmokers, p < 0… CONTINUE READING
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