Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.

@article{Xiong2006Tob1CD,
  title={Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.},
  author={Bo Xiong and Yanning Rui and Min Zhang and Kehui Shi and Shunji Jia and Tian Tian and Kun Yin and Huizhe Huang and Shu-Yong Lin and Xingang Zhao and Yinghua Chen and Ye-Guang Chen and Sheng-cai Lin and Anming Meng},
  journal={Developmental cell},
  year={2006},
  volume={11 2},
  pages={225-38}
}
Maternal beta-catenin and Nodal signals are essential for the formation of the dorsal organizer, which, in turn, induces neural and other dorsal tissue development in vertebrate embryos. Tob (Transducer of ErbB2) proteins possess antiproliferative properties and are known to influence BMP signaling, but their relationship to other signaling pathways and to embryonic patterning in general was unclear. In this study, we demonstrate that zebrafish tob1a is required for correct dorsoventral… CONTINUE READING

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