Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

@article{Matsuda1996TobAN,
  title={Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.},
  author={S Matsuda and Junko Kawamura-Tsuzuku and Miho Ohsugi and Mitsuhiro Yoshida and Mitsuru Emi and Yoko Nakamura and Masanori Onda and Yutaka Yoshida and Akira Nishiyama and Tadashi Yamamoto},
  journal={Oncogene},
  year={1996},
  volume={12 4},
  pages={705-13}
}
We have molecularly cloned a cDNA for a novel protein termed Tob (Transducer of ErbB-2) that interacts with the c-erbB-2 gene product p185erbB2. Nucleotide sequencing reveals that the Tob protein is a 45 kDa protein that does not contain either SH2 (Src Homology 2) or SH3 domain but is homologous to the previously characterized anti-proliferative gene product BTG-1 at its amino-terminal half. The carboxyl-terminal half of Tob is characterized by the presence of a sequence rich in proline and… CONTINUE READING