To treat or not to treat: the case of tuberculosis.

  title={To treat or not to treat: the case of tuberculosis.},
  author={Carlos Castillo-Chavez and Zhilan Feng},
  journal={Journal of mathematical biology},
  volume={35 6},
Incomplete treatment of patients with infectious tuberculosis (TB) may not only lead to relapse but also to the development of antibiotic resistant TB-one of the most serious health problems facing society today. In this article, we formulate one-strain and two-strain TB models to determine possible mechanisms that may allow for the survival and spread of naturally resistant strains of TB as well as antibiotic-generated resistant strains of TB. Analysis of our models shows that non-antibiotic… CONTINUE READING
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