To stop or not to stop? How long should medication treatment of attention-deficit hyperactivity disorder be extended?

@article{LooNeus2011ToSO,
  title={To stop or not to stop? How long should medication treatment of attention-deficit hyperactivity disorder be extended?},
  author={Gigi van de Loo-Neus and Nanda N. J. Rommelse and Jan K. Buitelaar},
  journal={European Neuropsychopharmacology},
  year={2011},
  volume={21},
  pages={584-599}
}

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References

SHOWING 1-10 OF 123 REFERENCES

Using Meta-analysis to Compare the Efficacy of Medications for Attention-Deficit/Hyperactivity Disorder in Youths.

  • S. Faraone
  • Psychology, Medicine
    P & T : a peer-reviewed journal for formulary management
  • 2009
Although nearly all of the ADHD medications had significant effects, there was substantial variability and when translated into the costs of treating large numbers of patients, these effect sizes have implications for formulary medication choices.

Relapse prevention in pediatric patients with ADHD treated with atomoxetine: a randomized, double-blind, placebo-controlled study.

In patients who responded favorably to 12 weeks of initial treatment, atomoxetine was superior to placebo in maintaining response for the ensuing 9 months, and this result supports the value of maintenance treatment with atomxetine in patients with ADHD who respond to initial treatment.

Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial.

The results of this long-term, placebo-controlled study of the central stimulant amphetamine in the treatment of ADHD indicate that there are remaining positive effects of the drug 15 months after starting treatment.

A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes.

Although both stimulant and nonstimulant medications are effective for treating ADHD in adults, stimulant medications show greater efficacy for the short durations of treatment characteristic of placebo-controlled studies.

Childhood hyperactivity and psychostimulants: a review of extended treatment studies.

Evidence from the more definitive randomized controlled trials indicates that stimulants are more effective in ameliorating the core behavioral symptoms of ADHD than placebos, nonpharmacological therapies, or no treatment-at least in 3-7-month trials.

Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder.

Long-term treatment with methylphenidate seems to be safe and effective for the management of ADHD behaviors in many (but not necessarily all) children with mild to moderate tic disorder.

A Randomized, Double-Blind Study of Continuation Treatment for Attention-Deficit/Hyperactivity Disorder After 1 Year

Long-Term Stimulant Medication Treatment of Attention-Deficit/Hyperactivity Disorder: Results from a Population-Based Study

It is demonstrated that the effectiveness of stimulant medication treatment of ADHD provided throughout childhood is comparable to the efficacy of Stimulant treatment demonstrated in clinical trials.

Treatment of ADHD in children with tics: a randomized controlled trial.

Methylphenidate and clonidine (particularly in combination) are effective for ADHD in children with comorbid tics, and prior recommendations to avoid methylphenidate in these children because of concerns of worsening tics are unsupported by this trial.

Treatment of ADHD in children with tics: A randomized controlled trial

  • S. Deputy
  • Medicine, Psychology
    Clinical pediatrics
  • 2002
Methylphenidate and clonidine (particularly in combination) are effective for ADHD in children with comorbid tics, and prior recommendations to avoid methylphenidate in these children because of concerns of worsening tics are unsupported by this trial.
...