To know or not to know: an update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk.

@article{Rahman2012ToKO,
  title={To know or not to know: an update of the literature on the psychological and behavioral impact of genetic testing for Alzheimer disease risk.},
  author={Belinda Rahman and Bettina Meiser and Perminder S. Sachdev and Kristine Barlow-Stewart and Margaret Otlowski and Elvira M. Zilliacus and Peter R. Schofield},
  journal={Genetic testing and molecular biomarkers},
  year={2012},
  volume={16 8},
  pages={935-42}
}
Alzheimer disease (AD) is a genetically heterogenous disorder; in rare cases autosomal dominantly inherited mutations typically cause early-onset familial AD (EOAD), whereas the risk for late-onset AD (LOAD) is generally modulated by genetic variants with relatively low penetrance but high prevalence, with variants in apolipoprotein E (APOE) being a firmly established risk factor. This article presents an overview of the current literature on the psychological and behavioral impact of genetic… CONTINUE READING