To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.

@article{He2002ToIA,
  title={To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon.},
  author={Yupeng He and Michael G. Katze},
  journal={Viral immunology},
  year={2002},
  volume={15 1},
  pages={
          95-119
        }
}
As popular strategies used by numerous viruses, interception of interferon (IFN) signaling and inhibition of IFN-induced antiviral functions allow viruses to evade the host immune response and set up successful infections. Hepatitis C virus (HCV), the leading cause of chronic liver disease worldwide and a major public health hazard, causes persistent infection in the majority of infected individuals. IFN-based therapies, currently the only ones available for HCV infection, have been unable to… CONTINUE READING

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