To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.

@article{Berwin2001ToFT,
  title={To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells.},
  author={Brent L. Berwin and Christopher V Nicchitta},
  journal={Traffic},
  year={2001},
  volume={2 10},
  pages={690-7}
}
Molecular chaperones, both endoplasmic reticulum and cytosol derived, have been identified as tumor rejection antigens; in animal models, they can elicit prophylactic and therapeutic immune responses against their tumor of origin. Chaperone immunogenic activity derives from three principal characteristics: they bind an array of immunogenic (poly)peptides, they can be efficiently internalized by professional antigen-presenting cells, and once internalized, they traffic to a subcellular… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…