To err (meiotically) is human: the genesis of human aneuploidy

@article{Hassold2001ToE,
  title={To err (meiotically) is human: the genesis of human aneuploidy},
  author={T. Hassold and P. Hunt},
  journal={Nature Reviews Genetics},
  year={2001},
  volume={2},
  pages={280-291}
}
Aneuploidy (trisomy or monosomy) is the most commonly identified chromosome abnormality in humans, occurring in at least 5% of all clinically recognized pregnancies. Most aneuploid conceptuses perish in utero, which makes this the leading genetic cause of pregnancy loss. However, some aneuploid fetuses survive to term and, as a class, aneuploidy is the most common known cause of mental retardation. Despite the devastating clinical consequences of aneuploidy, relatively little is known of how… Expand
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