To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.

@article{AlHamidi2010ToED,
  title={To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.},
  author={Hiba Al-Hamidi and Alison A Edwards and Mohammad Amin Mohammad and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2010},
  volume={76 1},
  pages={
          170-8
        }
}
The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however this is reliant on a suitable carrier and solvent being selected. The work presented explores D-glucosamine HCl (G-HCl) as a potential hydrophilic carrier to improve dissolution rate of a poorly water-soluble drug, carbamazepine (CBZ), from physical mixtures and solid dispersion formulations. The effect of different solvents in the preparation of solid dispersion… Expand
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